Synthesis and Biological Activity of Furan Containing Azitidinone Compounds

Published in Journal

Anusandhan (RNTUJ-AN) [RNTUJ-AN] (Vol:17/ Issue: 26) DOI: [NA]
Authors: Hitesh Kumar J. Gujjar1 Sheetal Gulati2 H.S.Patel3
Subjects: Science Technology and Management

Year: March.2021
Volume: 17 / Issue: 26
Pages: 2382-2387
Publisher: ANUSANDHAN(RNTUJ-AN)
Source:
ISSN: 2278-4187
E-ISSN: 2457-0656
DOI: NA
Published URL:
Published On: March.2021

Article Details

Synthesis and Biological Activity of Furan Containing Azitidinone Compounds | Original Article

Hitesh Kumar J. Gujjar1 Sheetal Gulati2 H.S.Patel3 in Anusandhan (RNTUJ-AN) | Multidisciplinary Academic Research

ABSTRACT:

ABSTRACT

The Schiff's bases (1a-e) based on 5-arylfurfural and Isoniazid prepared by us [1], were condensed with chloro acetyl chloride. The obtained 2-azitidinone derivatives were further treated respectively with sulphamethoxazole and morpholine. The so-called derivatives N-(2-(5-(4-alkylphenyl)furan-2-yl)-3-((4-(N-(isoxazol-3-yl)sulfamoyl) phenyl) amino) -4-oxoazetidin-1-yl) isonicotinamides (3a-e) and N-(2-(5-(4-alkylphenyl)furan-2-yl)-3-morpholino-4-oxoazetidin-1-yl)isonicotinamides (4a-e) and (2-azitidinone) were characterized by elemental content and spectral features. Their antimicrobial activity has also been monitored against common microbes.